Assessment of Vitamin D Status in Egyptian Children with Type-1 Diabetes Mellitus

Vitamin D and its active form are potent immune-modulators and are known to play an important role in the glucose/insulin metabolism. Studies on type 2 diabetes mellitus (T2DM) have shown that vitamin D increases insulin efficacy; However, there are no studies that define a similar relationship in type 1 diabetes mellitus (T1DM). Aim of the work: To evaluate serum vitamin D status in children with type 1 diabetes mellitus with comparison to healthy subjects and to correlate its level with different clinical and laboratory parameters. Subjects and methods: This study included two groups; Group I: included 53 patients with T1D; 43 patients with poor glycemic control (group Ia ) and 10 patients with good glycemic control (group Ib). Another 15 apparently healthy children and adolescent’s age and sex matched to the diseased group were taken as a control group and classified as group II. The studied groups were subjected to thorough history taking, clinical examination and laboratory investigations including: fasting blood glucose, glycated hemoglobin (HbA1c %), serum calcium level and 25-hydroxyvitD level. A serum 25OHD level of < 10 ng/mL was accepted as vitamin D deficiency, whereas < 20 ng/ mL was accepted as vitamin D insufficiency. Results: Serum 25-hydroxyvitD and serum calcium levels were significantly lower in T1D children than the control and in group Ia than group Ib. 25-hydroxyvitD had a significant strong positive correlation with serum calcium and significant strong negative correlations with fasting blood sugar and HbA1c %. Conclusion: T1D children had significantly lower serum 25hydroxyl vit D and serum calcium levels than the control group. Vitamin D in diabetic persons is an important factor in glycemic control with subsequent prevention of further complications. Assessment of Vitamin D Status in Egyptian Children with Type-1 Diabetes Mellitus Gamal Taha Soliman1, Basma Abdelmoez Ali1*, Ashraf Abdelfadeil Mohamed1, Ahmed Mohamed Mahmoud2 and Ahmed Abdelaziz Abdellatif1 1Pediatric Department, Faculty of Medicine, Minia University, Egypt 2Biochemistry Department, Faculty of Medicine, Minia University, Egypt *Corresponding author: Basma Abdelmoez Ali, Professor of pediatrics, Faculty of Medicine, Minia University, Egypt, Tel: 002 0100 6227847; 002 0862352728; E-mail: [email protected] Received May 20, 2015; Accepted June 22, 2015; Published June 26, 2015 Citation: Soliman GT, Ali BA, Mohamed AA, Mahmoud AM, Abdellatif AA (2015) Assessment of Vitamin D Status in Egyptian Children with Type-1 Diabetes Mellitus. J Diabetes Metab 6: 573. doi:10.4172/2155-6156.1000573 Copyright: © 2015 Soliman GT, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.